Detection of suspected placental invasion by MRI: Do the results depend on observer’ experience?

Authors: Leonor Alamo, Anass Anaye, Jannick Rey, Alban Denys, Georg Bongartz, Sylvain Terraz, Simona Artemisia, Reto Meuli, Sabine Schmidt


Purpose
To evaluate the diagnostic value of previously described MR features used for detecting suspected placental invasion according to observers’ experience.


Materials and methods

Our population included 25 pregnant women (mean age 35.16) investigated by prenatal MRI (1.5T, T1- and T2-weighted MR-sequences without i.v. contrast), among them 12 with histopathologically proven placental invasion and 13 women (52%) without placental invasion used as control group. Two senior and two junior radiologists blindly and independently reviewed MR-examinations in view of 6 previously defined MR-features indicating presence and degree of placental invasion (placenta increta, accreta or percreta). For each reader the sensibility, specificity, and receiver operating curve (ROC) were calculated. Interobserver agreements between senior and junior readers were determined. Stepwise logistic regression was performed including the 6 MR-features predictive of placental invasion.


Results

Demographics between both groups were statistically equivalent. Overall sensitivity and specificity for placental invasion was 90.9% and 75.0% for seniors and 81.8% and 61.8% for juniors, respectively. The best single MR-feature indicating placental invasion was T2-hypointense placental bands (r2=0.28), followed by focally interrupted myometrial border, infiltration of pelvic organs and tenting of the bladder (r2=0.36). Interobserver agreement for detecting placental invasion was 0.64 for seniors and 0.41 for juniors, thus substantial and moderate, respectively. Seniors detected placental invasion and depth of infiltration with significantly higher diagnostic certitude than juniors (p=0.0002 and p=0.0282, respectively).

Conclusion

MRI can be a reliable and reproducible tool for the detection of suspected placental invasion, but the diagnostic value significantly depends on observers’ experience.